4-Fluorobenzylamine → HCID 20222900, compound

HRID 979923Notes

Reaction equation

HRID 979923 reaction equation
[N:1]([CH2:4][CH:5]([O:8][CH3:9])[O:6][CH3:7])=[C:2]=[S:3].[F:10][C:11]1[CH:16]=[CH:15][C:14]([CH2:17][NH2:18])=[CH:13][CH:12]=1>O1CCCC1>[CH3:7][O:6][CH:5]([O:8][CH3:9])[CH2:4][NH:1][C:2]([NH:18][CH2:17][C:14]1[CH:15]=[CH:16][C:11]([F:10])=[CH:12][CH:13]=1)=[S:3]

Participants

4

Reactant 2

HCID 673264-FluorobenzylamineHCID 144710Isothiocyanatoacetaldehyde dimethyl acetal

Product 1

HCID 20222900HCID 20222900, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 4.8 parts of 1-isothiocyanato-2,2-dimethoxyethane, 4.2 parts of 4-fluorobenzenemethanamine and 90 parts of tetrahydrofuran was stirred overnight. The reaction mixture was evaporated, yielding 8.9 parts (99%) of N-(2,2-dimethoxyethyl)-N'-[(4-fluorophenyl)methyl]thiourea (188).

Workup

  1. customThe reaction mixture was evaporated

Sources & evidence

ORD record
ord-9bd70976f211457cba8a73591c25974b
Source dataset
uspto-grants-1987_01
Patent number
US04634704

Reaction notes

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