Morpholine → HCID 20222095, compound

HRID 980144Notes

Reaction equation

HRID 980144 reaction equation
[C:1]([C:4]1[CH:17]=[CH:16][C:7]([O:8][CH2:9][CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)=[CH:6][CH:5]=1)([OH:3])=O.S(Cl)(Cl)=O.[NH:22]1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1>C(OCC)(=O)C>[N:11]1([CH2:10][CH2:9][O:8][C:7]2[CH:16]=[CH:17][C:4]([C:1]([N:22]3[CH2:27][CH2:26][O:25][CH2:24][CH2:23]3)=[O:3])=[CH:5][CH:6]=2)[CH:15]=[CH:14][N:13]=[CH:12]1

Participants

5

Reactant 3

HCID 8083MorpholineHCID 24386Thionyl ChlorideHCID 53001Dazoxiben

Product 1

HCID 20222095HCID 20222095, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Successive treatment of 1-[2-(4-carboxyphenoxy)ethyl]imidazole (1.4 g) with thionyl chloride (1.4 g) and morpholine (10 ml) as described in Example 25 gave N-[4-(2-imidazol-1-yl)ethoxybenzoyl]morpholine, m.p. 109°-111° C. (from ethyl acetate). Found: C, 63.80; H, 6.40; N, 13.87. C16H19N3O3 requires: C, 63.77; H, 6.36; N, 13.94%.

Sources & evidence

ORD record
ord-1704bf9fff134f6286bc8616b5738600
Source dataset
uspto-grants-1987_01
Patent number
US04636500

Reaction notes

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