Oxirane, [[4-[2-(2-methylpropoxy)ethoxy]phenoxy]methyl]- → HCID 70438774, compound

HRID 980165Notes

Reaction equation

HRID 980165 reaction equation
[CH3:1][CH:2]([CH3:19])[CH2:3][O:4][CH2:5][CH2:6][O:7][C:8]1[CH:18]=[CH:17][C:11]([O:12][CH2:13][CH:14]2[O:16][CH2:15]2)=[CH:10][CH:9]=1.[NH2:20][CH2:21][CH2:22][NH:23][C:24]([NH:26][CH3:27])=[O:25]>C(O)(C)C>[OH:16][CH:14]([CH2:13][O:12][C:11]1[CH:17]=[CH:18][C:8]([O:7][CH2:6][CH2:5][O:4][CH2:3][CH:2]([CH3:19])[CH3:1])=[CH:9][CH:10]=1)[CH2:15][NH:20][CH2:21][CH2:22][NH:23][C:24]([NH:26][CH3:27])=[O:25]

Participants

4

Reactant 2

HCID 10635469Oxirane, [[4-[2-(2-methylpropoxy)ethoxy]phenoxy]methyl]-HCID 11857456Urea, N-(2-aminoethyl)-N'-methyl-

Product 1

HCID 70438774HCID 70438774, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

10.6 g of 3-(4-(2-(2-methylpropoxy)ethoxy)phenoxy)-1,2-epoxypropane and 14 g of N-2-aminoethyl-N'-methyl-urea was refluxed 40 h in isopropanol. The product crystallized when the heating was stopped. Recrystallized from isopropanol. Yield 8 g. M.p. 121° C. (base). The structure was determined using NMR.

Workup

  1. customThe product crystallized when the heating
  2. customRecrystallized from isopropanol

Sources & evidence

ORD record
ord-096c1730d29542e1964ef072ab8f057d
Source dataset
uspto-grants-1987_01
Patent number
US04636501

Reaction notes

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