5-Chloro-2(1H)-pyrimidinone → HCID 12795555, compound

HRID 980174Notes

Reaction equation

HRID 980174 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][C:5](=[O:8])[NH:6][CH:7]=1.Br[CH2:10][C:11]([C:13]1[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][C:14]=1[CH3:20])=[O:12]>C(N(CC)CC)C.C(O)C.O>[Cl:1][C:2]1[CH:3]=[N:4][C:5](=[O:8])[N:6]([CH2:10][C:11]([C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][C:14]=2[CH3:20])=[O:12])[CH:7]=1

Participants

6

Reactant 2

HCID 1085785-Chloro-2(1H)-pyrimidinoneHCID 20634502-Bromo-1-(2,4-dimethylphenyl)ethanone

Product 1

HCID 12795555HCID 12795555, compound

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 962WaterSolventHCID 8471TriethylamineSolvent

Procedure

A mixture of 5-chloropyrimidin-2-one (425 mg) and 2-bromo-2',4'-dimethylacetophenone (682 mg) in triethylamine (1 ml) and ethanol (20 ml) was stirred at ambient temperature for 2 hours. The reaction mixture was diluted with water and the solid filtered off.

Workup

  1. filtrationthe solid filtered off

Sources & evidence

ORD record
ord-5540877b26224e8b828787a6ee261479
Source dataset
uspto-grants-1987_01
Patent number
US04636509

Reaction notes

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