Trifluoroacetic acid → HCID 178522556, compound

HRID 980238Notes

Reaction equation

HRID 980238 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[C:7]([C:12]([F:15])([F:14])[F:13])[CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([C@@H:16]([NH:27][C:28](=O)OC(C)(C)C)[CH2:17][C:18]2C3C(=CC=CC=3)NC=2)[C:3]=1[C:35]([NH:37][C:38]1[S:39][CH:40]=[CH:41][N:42]=1)=[O:36].FC(F)(F)C(O)=O.FC(F)(F)C([O-])=O>C(Cl)Cl>[OH:1][C:2]1[C:11]2[C:6](=[C:7]([C:12]([F:13])([F:15])[F:14])[CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([C@@H:16]2[CH2:17][CH2:18][CH2:28][NH:27]2)[C:3]=1[C:35]([NH:37][C:38]1[S:39][CH:40]=[CH:41][N:42]=1)=[O:36]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 84468TrifluoroacetateHCID 178454163HCID 178454163, compound

Product 1

HCID 178522556HCID 178522556, compoundYield 150.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Using the procedure of Example 14, 7.8 g of the product of Example 11, 80 ml of methylene chloride, and 40 ml of trifluoroacetic acid were reacted to obtain 8.0 g of 4-hydroxy-2-[(2S) 2-pyrrolidinyl]-N-(2-thiazolyl)-8-trifluoromethyl-3-quinoline carboxamide in the form of its trifluoroacetate melting at 210° C.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-00eae502ec2d469f8e93150052ad87b1
Source dataset
uspto-grants-1987_01
Patent number
US04636512

Reaction notes

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