Methyl iodide → HCID 12822483, compound

HRID 980297Notes

Reaction equation

HRID 980297 reaction equation
[H-].[Na+].[O:3]=[C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[O:13])[N:5]1[CH2:14][CH2:15][C:16]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([CH2:25][NH:26][S:27]([CH3:30])(=[O:29])=[O:28])[CH:23]=2)[NH:18][CH:17]=1.[CH3:31]I>CN(C)C=O>[O:13]=[C:6]1[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:4](=[O:3])[N:5]1[CH2:14][CH2:15][C:16]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([CH2:25][N:26]([CH3:31])[S:27]([CH3:30])(=[O:29])=[O:28])[CH:23]=2)[NH:18][CH:17]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 12822470HCID 12822470, compound

Product 1

HCID 12822483HCID 12822483, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Sodium hydride (80% in oil; 0.1 g) was added under nitrogen to a stirred solution of N-[[3-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethyl]-1H-indol-5-yl]methyl]methanesulphonamide (1.2 g) in dry dimethylformamide (16 ml). After 1 h, methyl iodide (0.75 ml) was added.

Sources & evidence

ORD record
ord-fb7897237e6342d6ba98c39690b430ca
Source dataset
uspto-grants-1987_01
Patent number
US04636521

Reaction notes

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