N-(4-nitrobenzyl)methanesulfonamide → HCID 12822521, compound

HRID 980304Notes

Reaction equation

HRID 980304 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][NH:11][S:12]([CH3:15])(=[O:14])=[O:13])=[CH:6][CH:5]=1)([O-])=O.[H][H]>C(O)C.C(OCC)(=O)C.[Pd]=O>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][NH:11][S:12]([CH3:15])(=[O:14])=[O:13])=[CH:6][CH:5]=1

Participants

6

Reactant 2

HCID 12822520N-(4-nitrobenzyl)methanesulfonamideHCID 178418361HCID 178418361, compound

Product 1

HCID 12822521HCID 12822521, compound

Reagents, catalysts & solvents 3

HCID 5083724Palladium monoxideCatalystHCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

A solution of N-[(4-nitrophenyl)methyl]methanesulphonamide (2.5 g) in a mixture of ethanol (90 ml) and ethyl acetate (90 ml) was hydrogenated at room temperature and pressure over palladium oxide on charcoal (10%; 50% paste with water, 1 g) until uptake of hydrogen ceased (15 min., 820 ml).

Workup

  1. customwas hydrogenated at room temperature
  2. custom(15 min., 820 ml)

Sources & evidence

ORD record
ord-42ecaf5cc314497ba61cf02453a6baf6
Source dataset
uspto-grants-1987_01
Patent number
US04636521

Reaction notes

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