Formaldehyde → Hydrochloric Acid

HRID 980458Notes

Reaction equation

HRID 980458 reaction equation
[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11](=[O:14])[CH2:12][CH3:13])=[CH:7][CH:6]=1)[CH:2]([CH3:4])[CH3:3].[ClH:15].[NH:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1.C=O.[C:23](OCC)(=O)C.Cl>C(OCC)(=O)C>[ClH:15].[CH2:1]([C:5]1[CH:6]=[CH:7][C:8]([C:11](=[O:14])[CH:12]([CH3:23])[CH2:13][N:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)=[CH:9][CH:10]=1)[CH:2]([CH3:4])[CH3:3]

Participants

7

Reactant 4

HCID 712FormaldehydeHCID 1088341-(4-(2-Methylpropyl)phenyl)-1-propanoneHCID 212848Pyrrolidine, hydrochloride (1:1)HCID 21866389Hydrogen chloride-ethyl acetate

Product 2

HCID 313Hydrochloric AcidHCID 13478357HCID 13478357, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of 5.40 g of 4'-isobutylpropiophenone in 15 ml of ethyl acetate, 3.00 g of pyrrolidine hydrochloride, 1.30 g of paraformaldehyde and 0.5 ml of 22% hydrogen chloride-ethyl acetate were treated in the same manner as that described for Example 3 to give 3.53 g of hydrochloride of the desired compound which were recrystallized from methyl ethyl ketone as colorless scales, mp 127°-128°.

Sources & evidence

ORD record
ord-7f7e800ebed3480499a876c2f61ff156
Source dataset
uspto-grants-1987_01
Patent number
US04638009

Reaction notes

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