反应详情

温度

10 °C

To 0.3M of aluminum chloride in 500 ml of 1,2-dichloroethylene, 0.21M of propionyl chloride are added, then slowly while stirring 0.2M of 2,3-dihydrobenzo[b]thiophene are added, temperature being maintained at about 10° C. The mixture is then still stirred for 3 hours at room temperature, then decomposed with a mixture of ice and hydrochloric acid. The organic phase is separated and the aqueous phase is extracted with 1,2-dichloroethylene. The combined organic phases are dried on MgSO4, filtered and solvent is evaporated in a vacuum. The residence obtained is solidified by addition of petroleum ether: 25 gr. of 5-propionyl-2,3-dihydrobenzo[b]thiophene are so obtained.

1. additionare added
2. customThe organic phase is separated
3. extractionthe aqueous phase is extracted with 1,2-dichloroethylene
4. customThe combined organic phases are dried on MgSO4
5. filtrationfiltered
6. customsolvent is evaporated in a vacuum
7. customThe residence obtained