反应详情

Sodium iodide (687 mg) and sodium cyanoborohydride (576 mg) were added to a solution of crude p-nitrobenzyl 2-chloro-2-(4-methylthio-2-azetidinon-1-yl)acetate (1.58 g) in hexamethylphosphoramide (15 ml), and the resulting mixture was stirred at room temperature for an hour. The reaction mixture was then poured into ice-water and the precipitates produced were collected by filtration, washed with water, dried and recrystallized from ethyl acetate to afford 844 mg of the desired compound.

1. customthe precipitates produced
2. filtrationwere collected by filtration
3. washwashed with water
4. customdried
5. customrecrystallized from ethyl acetate