Hydrogen Bromide → HCID 9321153, compound

HRID 981048Notes

Reaction equation

HRID 981048 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=O)[C:5]2=O.[NH2:13][C:14]1[CH:21]=[C:20]([CH3:22])[CH:19]=[CH:18][C:15]=1[NH:16]C.Br.O>C(O)(=O)C>[CH3:22][C:20]1[CH:21]=[C:14]2[C:15](=[CH:18][CH:19]=1)[N:16]=[C:6]1[NH:7][C:8]3[CH:9]=[CH:10][C:2]([Br:1])=[CH:3][C:4]=3[C:5]1=[N:13]2

Participants

6

Reactant 4

HCID 260Hydrogen BromideHCID 962WaterHCID 68895-BromoisatinHCID 12198272HCID 12198272, compound

Product 1

HCID 9321153HCID 9321153, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 2.26 g 5-bromoisatin (0.01 mole) and 1.36 g 2-amino N-methyl-p-toluidine (0.01 mole) in 15 ml acetic acid is boiled with reflux for 45 minutes. Finally hydrogen bromide is introduced and the mixture is boiled for further 2 hours. After cooling it is poured into water. The dried reaction product is recrystallized from acetic acid.

Workup

  1. temperaturewith reflux for 45 minutes
  2. temperatureAfter cooling it
  3. customThe dried reaction product
  4. customis recrystallized from acetic acid

Sources & evidence

ORD record
ord-67f1013c7d0346239fa081c7ecfcada4
Source dataset
uspto-grants-1991_02
Patent number
US04990510

Reaction notes

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