Methane → HCID 178430573, compound

HRID 981122Notes

Reaction equation

HRID 981122 reaction equation
[CH2:1]([N:8]=[C:9]([C:11]1[NH:12][CH:13]=[C:14]([CH3:20])[CH2:15][C:16]=1[C:17]([OH:19])=[O:18])[OH:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C>O1CCCC1.[Pd]>[CH2:1]([N:8]=[C:9]([CH:11]1[CH:16]([C:17]([OH:19])=[O:18])[CH2:15][CH:14]([CH3:20])[CH2:13][NH:12]1)[OH:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 297MethaneHCID 178430572HCID 178430572, compound

Product 1

HCID 178430573HCID 178430573, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

17.5 g (70 mmol) of 5-methyl-1,4-dihydropyridine-2,3-dicarboxylic acid N-benzylimide are hydrogenated in 150 ml of tetrahydrofuran at 70° C. and under 100 bar over palladium on active charcoal. Then the catalyst is filtered off and the filtrate is concentrated by evaporation. The solid oily residue (13.0 g) is used as a crude product in the next stage.

Workup

  1. filtrationThen the catalyst is filtered off
  2. concentrationthe filtrate is concentrated by evaporation

Sources & evidence

ORD record
ord-370423a58e3f446d9008f640f3210ff2
Source dataset
uspto-grants-1991_02
Patent number
US04990517

Reaction notes

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