Trifluoroacetic anhydride → HCID 20071767, compound

HRID 981255Notes

Reaction equation

HRID 981255 reaction equation
[CH3:1][S:2]([C:4]1[CH:9]=[CH:8][C:7]([C:10](=[O:18])[CH:11]([CH3:17])[CH2:12][C:13]([O:15][CH3:16])=[O:14])=[CH:6][CH:5]=1)=O.[F:19][C:20]([F:31])([F:30])[C:21]([O:23]C(=O)C(F)(F)F)=[O:22]>>[F:19][C:20]([F:31])([F:30])[C:21]([O:23][CH2:1][S:2][C:4]1[CH:9]=[CH:8][C:7]([C:10](=[O:18])[CH:11]([CH3:17])[CH2:12][C:13]([O:15][CH3:16])=[O:14])=[CH:6][CH:5]=1)=[O:22]

Participants

3

Reactant 2

HCID 9845Trifluoroacetic anhydrideHCID 20071758HCID 20071758, compound

Product 1

HCID 20071767HCID 20071767, compound

Procedure

A solution of the sulfoxide from Step C of this Example (10 g) in trifluoroacetic anhydride (50 ml) was heated at 45° C. for 25 minutes and the mixture was evaporated, and then coevaporated with toluene, to dryness to give the title compound as an oil (15 g, crude) which was used directly in the following step.

Workup

  1. customwas heated at 45° C. for 25 minutes
  2. customthe mixture was evaporated

Sources & evidence

ORD record
ord-6676e588402743eda18ec160fd86ddfa
Source dataset
uspto-grants-1991_02
Patent number
US04990526

Reaction notes

Loading…