Hydrochloric Acid → HCID 178512798, compound

HRID 981585Notes

Reaction equation

HRID 981585 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11].[NH2:13][C:14]([NH2:16])=[NH:15].Cl>O1CCOCC1>[NH:15]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])[C:14]([NH2:16])=[NH:13]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3520GuanidineHCID 5482219-Bromononanoic Acid

Product 1

HCID 178512798HCID 178512798, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

9-Bromo-nonanoic acid (5 gm; 21.1 mmoles) was dissolved in dioxane (50 ml) and the free guanidine solution from A was added. The mixture was refluxed overnight, and the white precipitate was filtered and washed three times with cold water and then lyophilized from one equivalent of 0.5M HCl. The yield was 2.77 g (85%) and the structure of the title compound was verified by FAB-MS, NMR, and elemental analysis.

Workup

  1. temperatureThe mixture was refluxed overnight
  2. filtrationthe white precipitate was filtered
  3. washwashed three times with cold water

Sources & evidence

ORD record
ord-623dba4c588f4099b5fec4053f9ad3d4
Source dataset
uspto-grants-1991_02
Patent number
US04992463

Reaction notes

Loading…