反应详情

10.1 g (34 mmol) of 2-(4-fluorophenyl)-5-methyl-1-phenyl-hexane-1,4-dione (Example 2) and 9.3 mmol (102 mmol) of aniline in 150 ml of toluene are heated under reflux in a water separator for 24 hours with the addition of 500 mg of p-toluenesulphonic acid. After cooling and diluting with ethyl acetate, the reaction mixture is washed with 1 N hydrochloric acid and then with sodium bicarbonate solution, dried over magnesium sulphate and concentrated in vacuo. The residue is then chromatographed on silica gel.

1. temperatureAfter cooling
2. washthe reaction mixture is washed with 1 N hydrochloric acid
3. dry with materialwith sodium bicarbonate solution, dried over magnesium sulphate
4. concentrationconcentrated in vacuo
5. customThe residue is then chromatographed on silica gel