Trifluoroacetic anhydride → HCID 14988498, compound

HRID 981761Notes

Reaction equation

HRID 981761 reaction equation
[C:1]([OH:9])(=[O:8])[C@H:2]([CH2:4][C:5]([OH:7])=[O:6])[OH:3].FC(F)(F)C(O)=O.[C:17]1(=O)OC(=O)[CH2:20][C@@H:18]1O.FC(F)(F)C(OC(=O)C(F)(F)F)=O>C(O)(C)C>[CH:18]([O:8][C:1](=[O:9])[C@H:2]([CH2:4][C:5]([OH:7])=[O:6])[OH:3])([CH3:20])[CH3:17]

Participants

5

Reactant 3

HCID 9845Trifluoroacetic anhydrideHCID 222656L-Malic AcidHCID 131716795HCID 131716795, compound

Product 1

HCID 14988498HCID 14988498, compoundYield 97.7%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

By the use of the procedures and conditions described by Example 3A, L-malic acid was converted to L-malic anhydride trifluoroacetate with trifluoroacetic anhydride, and the anhydride allowed to react with isopropyl alcohol to provide in 97.7% yield L-malic acid monoisopropyl ester as an oil.

Sources & evidence

ORD record
ord-01d544a57f5049e2af31a21f3c89ef76
Source dataset
uspto-grants-1991_02
Patent number
US04992544

Reaction notes

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