Methylamine → HCID 13475742, compound

HRID 982010Notes

Reaction equation

HRID 982010 reaction equation
[CH3:1][N:2]([CH3:26])[CH2:3][CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([CH2:14][CH2:15][S:16]([O:19]C3C=CC=CC=3)(=[O:18])=O)[CH:12]=2)[NH:7][CH:6]=1.[CH3:27][NH2:28]>N1C=CC=CC=1>[CH3:26][N:2]([CH3:1])[CH2:3][CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([CH2:14][CH2:15][S:16]([NH:28][CH3:27])(=[O:18])=[O:19])[CH:12]=2)[NH:7][CH:6]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 20068950HCID 20068950, compound

Product 1

HCID 13475742HCID 13475742, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The product of stage (v) (70 mg) in a saturated solution of methylamine in pyridine (4 ml) was heated at 100° in a "reactival" for 1.5 h. The mixture was concentrated and the residue oil purified by column chromatography (B) to give the title compound as an oil (7 mg), which was shown by n.m.r. and t.l.c. (B, Rf 0.3) to be identical with the product of Example 10 method (I).

Workup

  1. concentrationThe mixture was concentrated
  2. customthe residue oil purified by column chromatography (B)

Sources & evidence

ORD record
ord-d63183aaa5d647598a5726c018b6630c
Source dataset
uspto-grants-1991_02
Patent number
US04994483

Reaction notes

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