反应详情

6 g of 2-methylthio-3,5-dicyano-4-hydroxythiophene 10 ml of methyl iodide, 10 g of potassium carbonate, and 3 ml of triethylamine are refluxed in 300 ml of acetonitrile while stirring. After 2 hours the reaction mixture is filtered warm and evaporated to dryness. The residue is taken up in 200 ml of methylene chloride and washed successively with a solution of potassium carbonate in water and with water. The methylene chloride solution is then dried and evaporated to dryness. After recrystallisation of the residue from isopropanol, the desired product is obtained in a yield of 4.0 g; melting-point 132° C.

1. filtrationAfter 2 hours the reaction mixture is filtered
2. temperaturewarm
3. customevaporated to dryness
4. washwashed successively with a solution of potassium carbonate in water and with water
5. dry with materialThe methylene chloride solution is then dried
6. customevaporated to dryness
7. customAfter recrystallisation of the residue from isopropanol