Dimethylformamide → N-(3-(2-chloro-6-iodo-4-morpholinothieno[3,2-d]pyrimidine-6-yl)phenyl)-N-methylacetamide

HRID 98203Notes

Reaction equation

HRID 98203 reaction equation
[C:28](=[O:29])([O-:30])[O-:31].[CH3:41][CH2:42][O:43][C:44](=[O:45])[CH3:46].[Cl:1][c:2]1[n:3][c:4]([N:22]2[CH2:23][CH2:24][O:25][CH2:26][CH2:27]2)[c:5]2[c:6]([n:7]1)[CH2:8][C:9]([I:11])([c:12]1[cH:13][c:14]([NH:18][C:19]([CH3:20])=[O:21])[cH:15][cH:16][cH:17]1)[S:10]2.[Cs+:32].[Cs+:33].[I:34][CH3:35].[O:36]=[CH:37][N:38]([CH3:39])[CH3:40]>>[Cl:1][c:2]1[n:3][c:4]([N:22]2[CH2:23][CH2:24][O:25][CH2:26][CH2:27]2)[c:5]2[c:6]([n:7]1)[CH2:8][C:9]([I:11])([c:12]1[cH:13][c:14]([N:18]([C:19]([CH3:20])=[O:21])[CH3:28])[cH:15][cH:16][cH:17]1)[S:10]2

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 6328Methyl iodideHCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 86618443HCID 86618443, compound

Product 1

HCID 86618444N-(3-(2-chloro-6-iodo-4-morpholinothieno[3,2-d]pyrimidine-6-yl)phenyl)-N-methylacetamide

Sources & evidence

ORD record
ord-02224cf2e22b48bf97b0cf75e7923879
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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