HRID982231

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8022

Ethyl isocyanate

C3H5NO

HCID8471

Triethylamine

C6H15N

结构：Cl.Nc1ccc(OCC(=O)O)c(NC(=O)c2ccc(OCCCCc3ccccc3)cc2)c1

HCID67944477

未命名化合物

PRODUCTS

生成物

结构：CCNC(=O)Nc1ccc(OCC(=O)OCC)c(NC(=O)c2ccc(OCCCCc3ccccc3)cc2)c1

HCID15106501

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

To a mixture of 200 mg of ethyl (4-amino-2-[p-(4-phenylbutoxy)benzamido]phenoxyacetate hydrochloride, 40.5 mg of triethylamine and 5 mg of methylene chloride was added 30 mg of ethyl isocyanate followed by stirring at room temperature overnight. The reaction mixture was treated in a manner similar to Example 68 to obtain 130 mg of ethyl 4-(3-ethylureido)-2-[p-(4-phenylbutoxy)benzamido]phenoxyacetate.

WORKUP

后处理

additionThe reaction mixture was treated in a manner similar to Example 68

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-644d20d173484364bbff9de7b8d5261b
来源数据集: uspto-grants-1991_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04994479
来源说明: uspto-grants-1991_02

反应 SMILES

Cl.[NH2:2][C:3]1[CH:13]=[CH:12][C:6]([O:7][CH2:8][C:9]([OH:11])=[O:10])=[C:5]([NH:14][C:15](=[O:33])[C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][CH2:25][CH2:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[CH:18][CH:17]=2)[CH:4]=1.[CH2:34](N(CC)CC)[CH3:35].[CH2:41]([N:43]=[C:44]=[O:45])[CH3:42]>C(Cl)Cl>[CH2:41]([NH:43][C:44](=[O:45])[NH:2][C:3]1[CH:13]=[CH:12][C:6]([O:7][CH2:8][C:9]([O:11][CH2:34][CH3:35])=[O:10])=[C:5]([NH:14][C:15](=[O:33])[C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][CH2:25][CH2:26][C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)=[CH:18][CH:17]=2)[CH:4]=1)[CH3:42]