Dimethylformamide → HCID 67923454, compound

HRID 982312Notes

Reaction equation

HRID 982312 reaction equation
[NH2:1][C:2]1[C:3]([CH3:20])=[CH:4][C:5]2[CH2:11][CH2:10][N:9]([CH3:12])[CH2:8][C@H:7]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:6]=2[CH:19]=1.[C:21]([OH:28])(=[O:27])/[CH:22]=[CH:23]\[C:24]([OH:26])=[O:25].CN(C=O)C>C(O)(C)C>[C:21]([OH:28])(=[O:27])/[CH:22]=[CH:23]\[C:24]([OH:26])=[O:25].[NH2:1][C:2]1[C:3]([CH3:20])=[CH:4][C:5]2[CH2:11][CH2:10][N:9]([CH3:12])[CH2:8][C@H:7]([C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:6]=2[CH:19]=1

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 444266Maleic AcidHCID 15132171HCID 15132171, compound

Product 1

HCID 67923454HCID 67923454, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

The product of Example V, part D above was treated with maleic acid (650 mg) in isopropanol, affording 1.50 g of the product of this example, m.p. 171°-174° C. [α]26D +9.80 (c=0.25, DMF).

Sources & evidence

ORD record
ord-b92b8a0cc9744c02ac3dd240560bdf48
Source dataset
uspto-grants-1991_02
Patent number
US04996202

Reaction notes

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