HCID 178497769, compound → HCID 178497768, compound

HRID 982316Notes

Reaction equation

HRID 982316 reaction equation
[OH:1][C:2]1[N:7]([C:8]#[C:9][C:10]2[CH:19]=[CH:18][C:13]([C:14]([O:16][CH3:17])=[O:15])=[CH:12][CH:11]=2)[CH:6]=[N:5][C:4]2=[N:20][C:21]([CH3:31])=[C:22](COC(=O)C(C)(C)C)[C:3]=12>CO.[Cl-].[Pd]>[OH:1][C:2]1[N:7]([CH2:8][CH2:9][C:10]2[CH:19]=[CH:18][C:13]([C:14]([O:16][CH3:17])=[O:15])=[CH:12][CH:11]=2)[CH:6]=[N:5][C:4]2=[N:20][C:21]([CH3:31])=[CH:22][C:3]=12

Participants

5

Reactant 1

HCID 178497769HCID 178497769, compound

Product 1

HCID 178497768HCID 178497768, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 312ChlorideSolventHCID 887MethanolSolvent

Procedure

A mixture of 1.0 g of methyl 4-(4-hydroxy-5-pivaloyloxymethyl-6-methylpyrrolo[2,3-d]pyrimidin-3-ylethynyl)benzoate in 250 mL of 50% methanol in methylyne chloride and 0.8 g of 3% palladium-on-carbon is hydrogenated under reduced pressure. The solid is collected and there is obtained methyl 4-[2-(4-hydroxy-6-methylpyrrolo[2,3-d]pyrimidin-3-yl)ethyl]benzoate.

Workup

  1. customThe solid is collected

Sources & evidence

ORD record
ord-f45e6e31d6d046b6bc749dadd3dc1f6b
Source dataset
uspto-grants-1991_02
Patent number
US04996206

Reaction notes

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