Dimethylformamide dimethyl acetal → HCID 69736561, compound

HRID 982590Notes

Reaction equation

HRID 982590 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8]([F:11])([CH3:10])[CH3:9])[N:5]=[C:4]([NH:12][CH:13]([CH:23]2[CH2:25][CH2:24]2)[CH2:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[N:3]=1.CO[CH:28](OC)[N:29]([CH3:31])[CH3:30]>C1(C)C=CC=CC=1>[CH3:28][N:29]([CH:31]=[N:1][C:2]1[N:7]=[C:6]([C:8]([F:11])([CH3:9])[CH3:10])[N:5]=[C:4]([NH:12][CH:13]([CH:23]2[CH2:24][CH2:25]2)[CH2:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[N:3]=1)[CH3:30]

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 15510116HCID 15510116, compound

Product 1

HCID 69736561HCID 69736561, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 1.71 g (5 mmol) of 2-amino-4-(1-fluoro-1-methylethyl)-6-(1-cyclopropyl-4-phenyl-1-butylamino)-1,3,5-triazine and 2 ml of N,N-dimethylformamide dimethyl acetal in 30 ml of toluene is refluxed for 2 hours. All volatile constituents are subsequently carefully distilled off. This gives 1.94 g (97.5% of theory) of 2-dimethylaminomethyleneamino-4-(1-fluoro-1-methylethyl)-6-(1-cyclopropyl-4-phenyl-1-butylamino)-1,3,5-triazine as colorless oil.

Workup

  1. distillationAll volatile constituents are subsequently carefully distilled off

Sources & evidence

ORD record
ord-a99d2ea41a5449dab744cabb29fa7ea0
Source dataset
uspto-grants-2005_03
Patent number
US06861389B2

Reaction notes

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