反应详情

温度

90 °C

To a stirring mixture of N-(4-chlorobenzyl)-7-hydroxy-2-iodothieno[3,2-b]pyridine-6-carboxamide (0.50 g, 1.12 mmol) in DMF (20 mL) in a pressure tube was added K2CO3 (0.31 g, 2.25 mmol). To the resulting suspension was added CH3I (0.335g, 2.36 mmol), the vessel capped and heated at 90° C. for 16 h. The resulting dark suspension was cooled to ambient temperature and poured into H2O (100 mL). The aqueous solution was extracted with CH2Cl2 (3×100 mL). The organic layers were combined, dried over MgSO4 and solvent removed to afford 0.38 g title compound as a yellow solid.

1. customthe vessel capped
2. temperatureThe resulting dark suspension was cooled to ambient temperature
3. extractionThe aqueous solution was extracted with CH2Cl2 (3×100 mL)
4. dry with materialdried over MgSO4 and solvent
5. customremoved