反应详情

温度

60 °C

Diisopropylethylamine (34 μL, 0.19 mmol) was added to a mixture of N-(4-chlorobenzyl)-2-(chloromethyl)-4-{2-[methoxy(methyl)amino]-2-oxoethyl}-7-oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamide (60 mg, 0.13 mmol) and 1-(2-furyl)-2-(methylamino)ethanol (27 mg, 0.19 mmol) in DMF (2.0 mL). The mixture was shaken at 60° C. for 3 hrs. The reaction was cooled to room temperature before the addition of water (5 mL). The resulting ppt was collected by filtration and washed with water. After drying in vacuo, the title compound was obtained as a pale yellow solid (41 mg).

1. filtrationThe resulting ppt was collected by filtration
2. washwashed with water
3. customAfter drying in vacuo