反应详情

温度

80 °C

To a solution of 2-(5-bromo-4-oxo-pentyl)-isoindole-1,3-dione [CAS 41306-64-3](12.4 g) in abs. DMF (50 ml) was added benzamidine 85% (5.65 g) and potassium carbonate (11.05 g). The reaction mixture was stirred at 80° C. for 4 h, concentrated under high vacuum, quenched with water and extracted with ethyl acetate. The organic phase was washed with ice/water and brine, dried over magnesium sulphate and concentrated. The residue was purified by chromatography on silica gel using methylene chloride/methanol 2 and 5% as eluent. The product fractions were combined and evaporated to dryness to obtain 2-[3-(2-phenyl-1H-imidazol-4-yl)-propyl]-isoindole-1,3-dione (8.95 g) as a light yellow foam.

1. concentrationconcentrated under high vacuum
2. customquenched with water
3. extractionextracted with ethyl acetate
4. washThe organic phase was washed with ice/water and brine
5. dry with materialdried over magnesium sulphate
6. concentrationconcentrated
7. customThe residue was purified by chromatography on silica gel
8. customevaporated to dryness