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HRID983177

反应详情

EQUATION

反应方程式

HRID 983177 的结构方程式

REACTANTS

反应物

4
结构：ClCCCl
HCID11

1,2-Dichloroethane

C2H4Cl2

结构：NC1CC1
HCID69828

Cyclopropanamine

C3H7N

结构：On1nnc2ccccc21
HCID75771

1-Hydroxybenzotriazole

C6H5N3O

结构：CC(C)(C)OC(=O)N1C[C@H](O)C[C@@H]1C(=O)O
HCID688616

(4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-D-proline

C10H17NO5

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1C[C@H](O)C[C@@H]1C(=O)NC1CC1
HCID69741572

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Cyclopropylamine was coupled with (2R,4R)-4-hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester (8 g), EDC, HOBt, TEA in DMF to give 5 g of (2R,4R)-2-cyclopropylcarbamoyl-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester as a white semi-solid.