Proline benzyl ester hydrochloride → HCID 22557512, compound

HRID 983913Notes

Reaction equation

HRID 983913 reaction equation
Cl.[CH2:2]([O:9][C:10](=[O:16])[C@@H:11]1[CH2:15][CH2:14][CH2:13][NH:12]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Cl.[C:18](Cl)(=[O:25])[C:19]1[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=1>N1C=CC=CC=1>[N:22]1[CH:23]=[CH:24][C:19]([C:18]([N:12]2[CH2:13][CH2:14][CH2:15][CH:11]2[C:10]([O:9][CH2:2][C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=2)=[O:16])=[O:25])=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 2733413Proline benzyl ester hydrochlorideHCID 12262826Isonicotinoyl chloride hydrochloride

Product 1

HCID 22557512HCID 22557512, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
10 °C

Procedure

L-Proline benzyl ester hydrochloride (2.42 g, 0.01 mol) dissolved in pyridine (80 ml) is treated in portions at 3° C. (ice-bath cooling) with isonicotinoyl chloride hydrochloride (1.78 g, 0.01 mol), the IT increasing to 10° C. After removing the ice bath, the mixture is stirred for 5 h, the batch turning greenish.

Workup

  1. additionis treated in portions at 3° C.
  2. customAfter removing the ice bath

Sources & evidence

ORD record
ord-61c6918c0194461abb1f36475a58f8d8
Source dataset
uspto-grants-2005_03
Patent number
US06867211B2

Reaction notes

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