反应详情

温度

60 °C

To a suspension of 2,6-dimethoxy-4-iodophenol (1.0 g) and potassium carbonate (938 mg) in DMF (10 mL) was added isopropyl iodide (507 mL). The mixture was stirred at 60° C. for 3 hours and evaporated. Ethyl acetate and water were added to the residue, the organic layer was separated, washed with brine, dried over anhydrous sodium sulfate and evaporated. The residue was applied to a column of silica gel using hexane-ethyl acetate (5:1) as an eluent to give the title compound.

1. customevaporated
2. additionEthyl acetate and water were added to the residue
3. customthe organic layer was separated
4. washwashed with brine
5. dry with materialdried over anhydrous sodium sulfate
6. customevaporated