Hydrochloric Acid → 4-[N-(4-methoxyphenyl)-N-[3-(3,4,5-trimethoxyphenyl)benzoyl]amino]piperidine hydrochloride

HRID 984239Notes

Reaction equation

HRID 984239 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([C:35]2[CH:40]=[CH:39][C:38]([O:41][CH3:42])=[CH:37][CH:36]=2)[C:15](=[O:34])[C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]3[CH:27]=[C:26]([O:28][CH3:29])[C:25]([O:30][CH3:31])=[C:24]([O:32][CH3:33])[CH:23]=3)[CH:17]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:43]>C(OCC)(=O)C>[ClH:43].[CH3:42][O:41][C:38]1[CH:37]=[CH:36][C:35]([N:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[C:15](=[O:34])[C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]3[CH:27]=[C:26]([O:28][CH3:29])[C:25]([O:30][CH3:31])=[C:24]([O:32][CH3:33])[CH:23]=3)[CH:17]=2)=[CH:40][CH:39]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 225579681-(tert-butoxycarbonyl)-4-[N-(4-methoxyphenyl)-N-[3-(3,4,5-trimethoxyphenyl)benzoyl]amino]piperidine

Product 1

HCID 225578774-[N-(4-methoxyphenyl)-N-[3-(3,4,5-trimethoxyphenyl)benzoyl]amino]piperidine hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a solution of 1-(tert-butoxycarbonyl)-4-[N-(4-methoxyphenyl)-N-[3-(3,4,5-trimethoxyphenyl)benzoyl]amino]piperidine (416 mg) in ethyl acetate (5 mL) was added 4 M hydrogen chloride in ethyl acetate (5 mL). The mixture was stirred at room temperature for 4 hr, resulting precipitates were collected and washed with ethyl acetate on a funnel to give the title compound.

Workup

  1. customresulting
  2. customprecipitates
  3. customwere collected
  4. washwashed with ethyl acetate on a funnel

Sources & evidence

ORD record
ord-d689a4972f0d4c00baf8ff835a89ee28
Source dataset
uspto-grants-2005_03
Patent number
US06867221B2

Reaction notes

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