p-Toluidine → para-methyl 4-Anilino-1-Boc-piperidine

HRID 984270Notes

Reaction equation

HRID 984270 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:15][C:16]1[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 7813p-ToluidineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 22557837para-methyl 4-Anilino-1-Boc-piperidine

Procedure

1-(tert-Butoxycarbonyl)-4-piperidone (5.00 g) and p-toluidine (2.56 g) was treated in the same manner as described in Preparation Example 37 to give white powder of the title compound.

Workup

  1. customas described in Preparation Example 37

Sources & evidence

ORD record
ord-ddbc3a7851f54c78b7064b29702697e4
Source dataset
uspto-grants-2005_03
Patent number
US06867221B2

Reaction notes

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