Diisobutylaluminum hydride → (E)-3-(4'-fluoro-biphenyl-4-yl)-but-2-en-1-ol

HRID 984424Notes

Reaction equation

HRID 984424 reaction equation
CC(C[AlH]CC(C)C)C.[F:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]2[CH:22]=[CH:21][C:20](/[C:23](/[CH3:30])=[CH:24]/[C:25](OCC)=[O:26])=[CH:19][CH:18]=2)=[CH:13][CH:12]=1>>[F:10][C:11]1[CH:12]=[CH:13][C:14]([C:17]2[CH:22]=[CH:21][C:20](/[C:23](/[CH3:30])=[CH:24]/[CH2:25][OH:26])=[CH:19][CH:18]=2)=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 14487Diisobutylaluminum hydrideHCID 22557664(E)-ethyl 3-(4'-fluoro-biphenyl-4-yl)-but-2-enoate

Product 1

HCID 58816048(E)-3-(4'-fluoro-biphenyl-4-yl)-but-2-en-1-ol

Procedure

The colourless solid (E)-3-(4′-fluoro-biphenyl-4-yl)-but-2-en-1-ol was prepared by DIBAL-H reduction of (E)-ethyl 3-(4′-fluoro-biphenyl-4-yl)-but-2-enoate as described for example 52b.

Sources & evidence

ORD record
ord-c526b4d1f2ee480ab667d545a624491f
Source dataset
uspto-grants-2005_03
Patent number
US06867218B2

Reaction notes

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