Ethane, 2-bromo-1,1-diethoxy- → 2-Amino-5-bromopyridine

HRID 984718Notes

Reaction equation

HRID 984718 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[CH:7]=1.C(OC(OCC)CBr)C>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[CH:7]=1.[NH2:10][C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][N:6]=1

Participants

4

Reactant 2

HCID 74852Ethane, 2-bromo-1,1-diethoxy-HCID 27955476-Bromoimidazo[1,2-a]pyridine

Product 2

HCID 706222-Amino-5-bromopyridineHCID 27955476-Bromoimidazo[1,2-a]pyridine

Procedure

According to a method known from a literature [M. Yamanaka et al., Chemical & Pharmaceutical Bulletin (Chem. Pharm. Bull.), 1991, vol. 39, p.1556], the title compound (Intermediate 109, 3.36 g) was obtained from commercially available bromoacetaldehyde-diethyl acetal (4.7 ml, WAKO) and 2-amino-5-bromopyridine (4.32 g, Ald). Mass (LCMS): 197 (M+), retention time: 0.73 minutes (elution condition: B).

Sources & evidence

ORD record
ord-30b518fc681a4e3da7a6051f0c4ff329
Source dataset
uspto-grants-2005_03
Patent number
US06867320B2

Reaction notes

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