Benzoic Acid → 1-Benzoylpiperazine

HRID 984751Notes

Reaction equation

HRID 984751 reaction equation
[C:1]([OH:9])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(OC([N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1)=O)(C)(C)C>>[C:1]([N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1)(=[O:9])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 243Benzoic AcidHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 7626541-Benzoylpiperazine

Procedure

This was similarly prepared from benzoic acid (5.02 g) and 1-(tert-butoxycarbonyl)piperazine (7.66 g) and the title compound was isolated as a white solid (7.7 g, 82%). LCMS: Rt 0.51 min; m/z 191 (MH+).

Sources & evidence

ORD record
ord-99a8681d739743e88b374893f91341f1
Source dataset
uspto-grants-2005_03
Patent number
US06867192B1

Reaction notes

Loading…