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HRID984804

反应详情

EQUATION

反应方程式

HRID 984804 的结构方程式

REACTANTS

反应物

2
结构：CCOC(C)=O
HCID8857

Ethyl acetate

C4H8O2

结构：CC(O)[C@H]1CC[C@H](CNC(=O)OCc2ccccc2)CC1
HCID178468164

未命名化合物

PRODUCTS

生成物

1
结构：CC(O)[C@H]1CC[C@H](CN)CC1
HCID178468162

未命名化合物

收率 0.1%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[OH-].[OH-].[Pd+2]
催化剂HCID9942167

Palladium hydroxide

H2O2Pd

结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

A 500 mL Parr bottle was charged with 400 mg Pd(OH)2, 7.0 g (24.1 mol) trans-(−)-[4-(1-hydroxy-ethyl)-cyclohexylmethyl]-carbamic acid benzyl ester, 125 mL ethyl acetate and 125 ml MeOH. The bottle was placed under 50 psi H2 and shaken for 2 hours. The suspension was then filtered through Celite and concentrated to give 3.6 g of a white solid.

WORKUP

后处理

  1. filtrationThe suspension was then filtered through Celite
  2. concentrationconcentrated