o-Xylyl bromide → HCID 759632, compound

HRID 984825Notes

Reaction equation

HRID 984825 reaction equation
[Cl:1][C:2]1[NH:11][C:10]2[C:9](=[O:12])[N:7]([CH3:8])[C:6](=[O:13])[N:5]([CH3:14])[C:4]=2[N:3]=1.[CH3:15][C:16]1[CH:23]=[CH:22][CH:21]=[CH:20][C:17]=1[CH2:18]Br.C(Br)C1C=CC=CC=1>>[Cl:1][C:2]1[N:11]([CH2:15][C:16]2[CH:23]=[CH:22][CH:21]=[CH:20][C:17]=2[CH3:18])[C:10]2[C:9](=[O:12])[N:7]([CH3:8])[C:6](=[O:13])[N:5]([CH3:14])[C:4]=2[N:3]=1

Participants

4

Reactant 3

HCID 6992o-Xylyl bromideHCID 7498Benzyl BromideHCID 106618-Chlorotheophylline

Product 1

HCID 759632HCID 759632, compound

Procedure

From 8-Chorotheophylline (10 g, 47 mmol) and 2-methylbenzyl bromide (13.6 ml, 103 mmol). The benzyl bromide was added in two portions. First half at reaction start as described in general procedure (E), and the other half after 24 hours as the reaction had not completed.

Workup

  1. customFirst half at reaction start

Sources & evidence

ORD record
ord-71293e7cd549451b8a8716f32fa2a1bf
Source dataset
uspto-grants-2005_03
Patent number
US06869947B2

Reaction notes

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