Hydrochloric Acid → HCID 21991412, compound

HRID 984972Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[C:16](=[O:33])[N:17]([CH2:29][CH:30]([CH3:32])[CH3:31])[N:18]=[C:19]([C:21]3[CH:26]=[CH:25][C:24]([CH3:27])=[C:23]([F:28])[CH:22]=3)[CH:20]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:34].C(OCC)C>C(OCC)(=O)C>[ClH:34].[ClH:34].[F:28][C:23]1[CH:22]=[C:21]([C:19]2[CH:20]=[C:15]([CH2:14][N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)[C:16](=[O:33])[N:17]([CH2:29][CH:30]([CH3:31])[CH3:32])[N:18]=2)[CH:26]=[CH:25][C:24]=1[CH3:27]

Participants

Conditions

Temperature: 50 °C

Procedure

To a solution of 4-(4-tert-butoxycarbonyl-1-piperazinyl)methyl-6-(3-fluoro-4-methylphenyl)-2-isobutyl-2H-pyridazin-3-one (115 mg, 0.25 mmol) in ethyl acetate (2 mL) was added a 4 mol/L solution (2 mL) of hydrochloric acid in ethyl acetate, and the mixture was stirred at 50° C. for 1 hour. The temperature of the reaction mixture was allowed to drop back to room temperature, and then, diethyl ether was added. The precipitate was collected to yield the title compound as a colorless crystalline powder (81.1 mg, 75.0%).

Workup

customto drop back to room temperature
customThe precipitate was collected

Sources & evidence

ORD record: ord-919a59ca31a6478c8227c5d3036fe2a6
Source dataset: uspto-grants-2005_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06869954B2

Reaction notes

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