Hydrochloric Acid → HCID 22506966, compound

HRID 985406Notes

Reaction equation

HRID 985406 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[N:10]=[N:11][C:12]([O:15]C)=[CH:13][CH:14]=2)=[CH:4][CH:3]=1.Cl>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:14]=[CH:13][C:12](=[O:15])[NH:11][N:10]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 22506964HCID 22506964, compound

Product 1

HCID 22506966HCID 22506966, compoundYield 65%

Procedure

A mixture of 3-(4-fluoro-phenylsulfanyl)-6-methoxy-pyridazine (250 mg), prepared by a procedure analogous to step A of Example 2, and concentrated hydrochloric acid was prepared and refluxed for 30 minutes. The mixture was then evaporated to dryness. The resulting residue was purified by silica gel chromatography (ethyl acetate as eluent) to afford the title compound (65%, 152 mg); mp, 99-101° C.

Workup

  1. customwas prepared
  2. temperaturerefluxed for 30 minutes
  3. customThe mixture was then evaporated to dryness
  4. customThe resulting residue was purified by silica gel chromatography (ethyl acetate as eluent)

Sources & evidence

ORD record
ord-a03bc2d0880d4b628a4e2caf81d54fa3
Source dataset
uspto-grants-2005_03
Patent number
US06872722B2

Reaction notes

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