Sodium Hydroxide → HCID 22507060, compound

HRID 985453Notes

Reaction equation

HRID 985453 reaction equation
[CH:1]([NH:3][C:4]1[CH:9]=[CH:8][C:7]([CH3:10])=[CH:6][C:5]=1[N+:11]([O-:13])=[O:12])=O.[H-].[Na+].ClC1[N:22]=[C:21]([O:23][CH3:24])[N:20]=[C:19]([O:25][CH3:26])[N:18]=1.[OH-].[Na+]>O1CCCC1>[CH3:26][O:25][C:19]1[N:20]=[C:21]([O:23][CH3:24])[N:22]=[C:1]([NH:3][C:4]2[CH:9]=[CH:8][C:7]([CH3:10])=[CH:6][C:5]=2[N+:11]([O-:13])=[O:12])[N:18]=1

Participants

6

Reactant 4

HCID 14798Sodium HydroxideHCID 184502-Chloro-4,6-dimethoxy-1,3,5-triazineHCID 24758Sodium hydrideHCID 345693771894-91-2

Product 1

HCID 22507060HCID 22507060, compoundYield 86.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

N-formyl-4-methyl-2-nitroaniline (7.2 g) was dissolved in tetrahydrofuran (50 ml), and sodium hydride (60% purity, oily) (2.0 g) was added thereto at room temperature. After stirring for 10 minutes, 2-chloro-4,6-dimethoxy-[1,3,5]triazine (7.0 g) was added at room temperature, followed by stirring for 3 hours. A 10% aqueous sodium hydroxide solution was added thereto, and the crystals were collected by filtration, washed with water and dried to obtain 10.0 g of the desired product as a yellow powder (m.p. 189-191° C.)

Workup

  1. customat room temperature
  2. stirringby stirring for 3 hours
  3. filtrationthe crystals were collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-10a9d137d37344929d1fd0ba82b29cd3
Source dataset
uspto-grants-2005_03
Patent number
US06872729B2

Reaction notes

Loading…