Dichloromethane → [2-(2-Hydroxymethyl-phenyl)-6-methoxy-naphthalen-1-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanol

HRID 98556Notes

Reaction equation

HRID 98556 reaction equation
[Al+3:2].[CH2:44]1[O:45][CH2:46][CH2:47][CH2:48]1.[Cl:49][CH2:50][Cl:51].[H-:1].[H-:4].[H-:5].[H-:6].[Li+:3].[OH:7][CH2:8][c:9]1[c:10](-[c:15]2[c:16]([C:27](=[O:28])[c:29]3[cH:30][cH:31][c:32]([O:35][CH2:36][CH2:37][N:38]4[CH2:39][CH2:40][CH2:41][CH2:42][CH2:43]4)[cH:33][cH:34]3)[c:17]3[cH:18][cH:19][c:20]([O:25][CH3:26])[cH:21][c:22]3[cH:23][cH:24]2)[cH:11][cH:12][cH:13][cH:14]1>>[OH:7][CH2:8][c:9]1[c:10](-[c:15]2[c:16]([CH:27]([OH:28])[c:29]3[cH:30][cH:31][c:32]([O:35][CH2:36][CH2:37][N:38]4[CH2:39][CH2:40][CH2:41][CH2:42][CH2:43]4)[cH:33][cH:34]3)[c:17]3[cH:18][cH:19][c:20]([O:25][CH3:26])[cH:21][c:22]3[cH:23][cH:24]2)[cH:11][cH:12][cH:13][cH:14]1

Participants

7

Reactant 6

HCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 17987067[2-(2-Hydroxymethyl-phenyl)-6-methoxy-naphthalen-1-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone

Product 1

HCID 17987053[2-(2-Hydroxymethyl-phenyl)-6-methoxy-naphthalen-1-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanol

Sources & evidence

ORD record
ord-d8bd21bfd81c41999a55a727191c2f4c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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