Trifluoroacetic acid → (2R)-2-Amino-3-phenylpropyl 2,2-dimethylpropanoate

HRID 985569Notes

Reaction equation

HRID 985569 reaction equation
[C:1]([O:7][CH2:8][C@H:9]([NH:17]C(OC(C)(C)C)=O)[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3].FC(F)(F)C(O)=O>C(Cl)Cl>[C:1]([O:7][CH2:8][C@H:9]([NH2:17])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69736612HCID 69736612, compound

Product 1

HCID 69527907(2R)-2-Amino-3-phenylpropyl 2,2-dimethylpropanoate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A cooled solution of compound 94 (1.006 g, 3 mmol) in CH2Cl2 (10 ml) at 0° C. was treated with trifluoroacetic acid (2.5 ml) and stirred for 1 hr at room temperature. The mixture was concentrated in vacuo to give compound 96 as a yellow oil which was used for the next step without further purification.

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-3f18fdce92c64c9a8e2c28d655cdfefb
Source dataset
uspto-grants-2005_03
Patent number
US06872748B2

Reaction notes

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