反应详情

3 eq. of diborane in tetrahydrofuran and 1 eq. of the nitrile obtained in Step D are introduced into a 100 ml round-bottomed flask, and the mixture is then heated at reflux for 2 hours. After cooling, 15 eq. of 6M HCl are added and the tetrahydrofuran is evaporated off under reduced pressure. The precipitate formed is filtered off and recrystallised.

1. temperaturethe mixture is then heated
2. temperatureat reflux for 2 hours
3. temperatureAfter cooling
4. customthe tetrahydrofuran is evaporated off under reduced pressure
5. customThe precipitate formed
6. filtrationis filtered off
7. customrecrystallised