反应详情

An aqueous 0.5N solution of K2CO3 (10 ml) is added to the product obtained in Step A (4 mmol) dissolved in methanol (10 ml). When the reaction has ceased, the solution is acidified to pH 6-7 using 1N hydrochloric acid solution. The reaction mixture is extracted with dichloromethane. The organic phase is washed with water, dried over magnesium sulphate and concentrated under reduced pressure. The residue is chromatographed on silica gel to yield the title product.

1. extractionThe reaction mixture is extracted with dichloromethane
2. washThe organic phase is washed with water
3. dry with materialdried over magnesium sulphate
4. concentrationconcentrated under reduced pressure
5. customThe residue is chromatographed on silica gel