Diisopropylethylamine → HCID 22507729, compound

HRID 985795Notes

Reaction equation

HRID 985795 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][N:13]=1)[C:8]([OH:10])=O)([CH3:4])([CH3:3])[CH3:2].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C(N(C(C)C)C(C)C)C.[O:47]1[CH2:52][CH2:51][O:50][CH2:49][CH:48]1[C:53]1[C:61]2[S:60][C:59]([NH2:62])=[N:58][C:57]=2[C:56]([O:63][CH3:64])=[CH:55][CH:54]=1>C1COCC1>[C:1]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][N:13]=1)[C:8]([NH:62][C:59]1[S:60][C:61]2[C:53]([CH:48]3[CH2:49][O:50][CH2:51][CH2:52][O:47]3)=[CH:54][CH:55]=[C:56]([O:63][CH3:64])[C:57]=2[N:58]=1)=[O:10])([CH3:2])([CH3:3])[CH3:4]

Participants

6

Reactant 4

HCID 81531DiisopropylethylamineHCID 6932922-(tert-Butyl)isonicotinic acidHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 22507697(+)-7-[1,4)Dioxan-2-yl-4-methoxy-benzothiazol-2-ylamine

Product 1

HCID 22507729HCID 22507729, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

From 2-tert-butyl-isonicotinic acid, HATU and N-ethyldiisopropylamine in THF, then treatment with (±)-7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-ylamine. ES-MS m/e (%): 428 (M+H+, 100).

Sources & evidence

ORD record
ord-2894967aa2c441418d9b9c59011f3a0f
Source dataset
uspto-grants-2005_03
Patent number
US06872833B2

Reaction notes

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