Diisopropylethylamine → HCID 22507723, compound

HRID 985845Notes

Reaction equation

HRID 985845 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][C:5]([OH:7])=O.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C(N(C(C)C)C(C)C)C.[O:41]1[CH2:46][CH2:45][O:44][CH2:43][CH:42]1[C:47]1[C:55]2[S:54][C:53]([NH2:56])=[N:52][C:51]=2[C:50]([O:57][CH3:58])=[CH:49][CH:48]=1>C1COCC1.C(Cl)(Cl)Cl>[O:41]1[CH2:46][CH2:45][O:44][CH2:43][CH:42]1[C:47]1[C:55]2[S:54][C:53]([NH:56][C:5](=[O:7])[CH2:4][CH2:3][O:2][CH3:1])=[N:52][C:51]=2[C:50]([O:57][CH3:58])=[CH:49][CH:48]=1

Participants

7

Reactant 4

HCID 81531DiisopropylethylamineHCID 1344423-Methoxypropionic acidHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 22507697(+)-7-[1,4)Dioxan-2-yl-4-methoxy-benzothiazol-2-ylamine

Product 1

HCID 22507723HCID 22507723, compound

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 8028TetrahydrofuranSolvent

Procedure

From 3-methoxypropionic acid, HATU and N-ethyldiisopropylamine in THF, then treatment with (+)-7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-ylamine. [α]D20=+24.4° (c=1.02, CHCl3), ES-MS m/e (%): 353 (M+H+, 100).

Sources & evidence

ORD record
ord-dcee867cf25c48fe94239a14ca97ce45
Source dataset
uspto-grants-2005_03
Patent number
US06872833B2

Reaction notes

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