Chloroform → HCID 22507757, compound

HRID 985846Notes

Reaction equation

HRID 985846 reaction equation
CN(C(ON1N=N[C:11]2[CH:12]=[CH:13]C=N[C:10]1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C(N(C(C)C)C(C)C)C.[O:34]1[CH2:39][CH2:38][O:37][CH2:36][CH:35]1[C:40]1[C:48]2[S:47][C:46]([NH2:49])=[N:45][C:44]=2[C:43]([O:50][CH3:51])=[CH:42][CH:41]=1.C(Cl)(Cl)Cl.[CH2:56]1[CH2:60][O:59][CH2:58][CH2:57]1>>[CH:56]1([CH2:57][C:58]([NH:49][C:46]2[S:47][C:48]3[C:40]([CH:35]4[CH2:36][O:37][CH2:38][CH2:39][O:34]4)=[CH:41][CH:42]=[C:43]([O:50][CH3:51])[C:44]=3[N:45]=2)=[O:59])[CH2:60][CH2:13][CH2:12][CH2:11][CH2:10]1

Participants

6

Reactant 5

HCID 6212ChloroformHCID 8028TetrahydrofuranHCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 22507697(+)-7-[1,4)Dioxan-2-yl-4-methoxy-benzothiazol-2-ylamine

Product 1

HCID 22507757HCID 22507757, compound

Procedure

From cyclohexylacetic add, HATU and N-ethyldiisopropylamine in THF, then treatment with (+)-7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-ylamine. [α]D20=+19.3° (c=1.02, CHCl3), ES-MS m/e (%): 391 (M+H+, 100).

Sources & evidence

ORD record
ord-447b84b60d344aadb9a5f37b0f83739a
Source dataset
uspto-grants-2005_03
Patent number
US06872833B2

Reaction notes

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