Cyclohexanecarboxylic acid → HCID 86594656, compound

HRID 985853Notes

Reaction equation

HRID 985853 reaction equation
[CH:1]1([C:7]([OH:9])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C(N(C(C)C)C(C)C)C.[O:43]1[CH2:48][CH2:47][O:46][CH2:45][CH:44]1[C:49]1[C:57]2[S:56][C:55]([NH2:58])=[N:54][C:53]=2[C:52]([O:59][CH3:60])=[CH:51][CH:50]=1>C1COCC1.C(Cl)(Cl)Cl>[O:43]1[CH2:48][CH2:47][O:46][CH2:45][CH:44]1[C:49]1[C:57]2[S:56][C:55]([NH:58][C:7]([CH:1]3[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]3)=[O:9])=[N:54][C:53]=2[C:52]([O:59][CH3:60])=[CH:51][CH:50]=1

Participants

7

Reactant 4

HCID 7413Cyclohexanecarboxylic acidHCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 22507697(+)-7-[1,4)Dioxan-2-yl-4-methoxy-benzothiazol-2-ylamine

Product 1

HCID 86594656HCID 86594656, compound

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 8028TetrahydrofuranSolvent

Procedure

From cyclohexanecarboxylic acid, HATU and N-ethyldiisopropylamine in THF, then treatment with (+)-7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-ylamine. [α]D20=+19.2° (c=1.05, CHCl3), ES-MS m/e (%): 377 (M+H+, 100).

Sources & evidence

ORD record
ord-53403f9292b64d3ebbac9dc7bb351339
Source dataset
uspto-grants-2005_03
Patent number
US06872833B2

Reaction notes

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