Diisopropylethylamine → HCID 22507719, compound

HRID 985855Notes

Reaction equation

HRID 985855 reaction equation
[CH:1]1([CH2:4][O:5][CH2:6][C:7]2[CH:8]=[C:9]([CH:13]=[CH:14][N:15]=2)[C:10]([OH:12])=O)[CH2:3][CH2:2]1.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C(N(C(C)C)C(C)C)C.[O:49]1[CH2:54][CH2:53][O:52][CH2:51][CH:50]1[C:55]1[C:63]2[S:62][C:61]([NH2:64])=[N:60][C:59]=2[C:58]([O:65][CH3:66])=[CH:57][CH:56]=1>C1COCC1.C(Cl)(Cl)Cl>[CH:1]1([CH2:4][O:5][CH2:6][C:7]2[CH:8]=[C:9]([CH:13]=[CH:14][N:15]=2)[C:10]([NH:64][C:61]2[S:62][C:63]3[C:55]([CH:50]4[CH2:51][O:52][CH2:53][CH2:54][O:49]4)=[CH:56][CH:57]=[C:58]([O:65][CH3:66])[C:59]=3[N:60]=2)=[O:12])[CH2:2][CH2:3]1

Participants

7

Reactant 4

HCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 22507697(+)-7-[1,4)Dioxan-2-yl-4-methoxy-benzothiazol-2-ylamineHCID 22507734HCID 22507734, compound

Product 1

HCID 22507719HCID 22507719, compound

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 8028TetrahydrofuranSolvent

Procedure

From 2-cyclopropylmethoxymethyl-isonicotinic acid, HATU and N-ethyldiisopropylamine in THF, then treatment with (+)-7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-ylamine. [α]D20=+6.7° (c=1.04, CHCl3), ES-MS m/e (%): 456 (M+H+, 100).

Sources & evidence

ORD record
ord-f0e11f96a2e748a5ba7aec9c7fff5665
Source dataset
uspto-grants-2005_03
Patent number
US06872833B2

Reaction notes

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