Diisopropylethylamine → HCID 22507691, compound

HRID 985857Notes

Reaction equation

HRID 985857 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([O:7][CH2:8][C:9]2[CH:10]=[C:11]([CH:15]=[CH:16][N:17]=2)[C:12]([OH:14])=O)[CH2:3][CH2:2]1.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C(N(C(C)C)C(C)C)C.[O:51]1[CH2:56][CH2:55][O:54][CH2:53][CH:52]1[C:57]1[C:65]2[S:64][C:63]([NH2:66])=[N:62][C:61]=2[C:60]([O:67][CH3:68])=[CH:59][CH:58]=1>C1COCC1.C(Cl)(Cl)Cl>[O:51]1[CH2:56][CH2:55][O:54][CH2:53][CH:52]1[C:57]1[C:65]2[S:64][C:63]([NH:66][C:12](=[O:14])[C:11]3[CH:15]=[CH:16][N:17]=[C:9]([CH2:8][O:7][CH:4]4[CH2:3][CH2:2][O:1][CH2:6][CH2:5]4)[CH:10]=3)=[N:62][C:61]=2[C:60]([O:67][CH3:68])=[CH:59][CH:58]=1

Participants

7

Reactant 4

HCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 22507697(+)-7-[1,4)Dioxan-2-yl-4-methoxy-benzothiazol-2-ylamineHCID 22507703HCID 22507703, compound

Product 1

HCID 22507691HCID 22507691, compound

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 8028TetrahydrofuranSolvent

Procedure

From 2-(tetrahydro-pyran-4-yloxymethyl)-isonicotinic acid, HATU and N-ethyldiisopropylamine in THF, then treatment with (+)-7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-ylamine. [α]D20=+84.9° (c=1.05, CHCl3), ES-MS m/e (%): 486 (M+H+, 100).

Sources & evidence

ORD record
ord-a8c04aec6a1947ae9cc12110af5d6ca4
Source dataset
uspto-grants-2005_03
Patent number
US06872833B2

Reaction notes

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