Diisopropylethylamine → HCID 22507750, compound

HRID 985860Notes

Reaction equation

HRID 985860 reaction equation
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][CH2:8][O:9][CH2:10][C:11]1[CH:12]=[C:13]([CH:17]=[CH:18][N:19]=1)[C:14]([OH:16])=O.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C(N(C(C)C)C(C)C)C.[O:53]1[CH2:58][CH2:57][O:56][CH2:55][CH:54]1[C:59]1[C:67]2[S:66][C:65]([NH2:68])=[N:64][C:63]=2[C:62]([O:69][CH3:70])=[CH:61][CH:60]=1>C1COCC1.C(Cl)(Cl)Cl>[O:53]1[CH2:58][CH2:57][O:56][CH2:55][CH:54]1[C:59]1[C:67]2[S:66][C:65]([NH:68][C:14](=[O:16])[C:13]3[CH:17]=[CH:18][N:19]=[C:11]([CH2:10][O:9][CH2:8][CH2:7][N:3]4[CH2:4][CH2:5][CH2:6][C:2]4=[O:1])[CH:12]=3)=[N:64][C:63]=2[C:62]([O:69][CH3:70])=[CH:61][CH:60]=1

Participants

7

Reactant 4

HCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 22507697(+)-7-[1,4)Dioxan-2-yl-4-methoxy-benzothiazol-2-ylamineHCID 22507701HCID 22507701, compound

Product 1

HCID 22507750HCID 22507750, compound

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 8028TetrahydrofuranSolvent

Procedure

From 2-[2-(2-oxo-pyrrolidin-1-yl)-ethoxymethyl]-isonicotinic acid, HATU and N-ethyldiisopropylamine in THF, then treatment with (+)-7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-ylamine. [α]D20=+84.1° (c=1.02, CHCl3), ES-MS m/e (%): 513 (M+H+, 100).

Sources & evidence

ORD record
ord-5a5d5f440c214c1385fec8196abc37b6
Source dataset
uspto-grants-2005_03
Patent number
US06872833B2

Reaction notes

Loading…